ALOE-EMODIN EFFECTS ON ARYLAMINE N-ACETYLTRANSFERASE ACTIVITY IN THE BACTERIUM HELICOBACTER-PYLORI

Arylamine N-acetyltransferase (NAT) activities with p-aminobenzoic aci d (PABA) and 2-aminofluorene (AF) were determined in H. pylori collect ed from peptic ulcer patients. Cytosols or suspensions of H. pylori wi th or without different concentrations of aloe-emodin co-treatment sho wed different percentages of AF and PABA acetylation. The data indicat e that there was decreased NAT activity associated with increased aloe -emodin in H. pylori cytosols. Inhibition of growth study from H. pylo ri demonstrated that aloe-emodin elicited dose-dependent growth inhibi tion in H. pylori cultures, The report is the first finding of aloe-em odin inhibition of arylamine NAT activity in a strain of H. pylori.