ALKAMIDES FROM PHYLLANTHUS-FRATERNUS

Authors
SITTIE AA LEMMICH E OLSEN CE HVIID L CHRISTENSEN SB
Citation
Aa. Sittie et al., ALKAMIDES FROM PHYLLANTHUS-FRATERNUS, Planta medica, 64(2), 1998, pp. 192-193
Citations number
11
Categorie Soggetti
Pharmacology & Pharmacy","Plant Sciences","Chemistry Medicinal
Journal title
Planta medica → ACNP
ISSN journal
00320943
Volume
64
Issue
2
Year of publication
1998
Pages
192 - 193
Database
ISI
SICI code
0032-0943(1998)64:2<192:AFP>2.0.ZU;2-N
Abstract
Two alkamides E,E-2,4-octadienamide and E,Z-2,4-decadienamide have bee n isolated from Phyllanthus fraternus, a plant used in Ghanaian tradit ional medicine to treat malaria. The compounds possess an alpha,beta,g amma,delta-unsaturated conjugated amide, a feature believed to enhance antiplasmodial activity. By means of an in vitro assay the two alkami des have been shown to possess moderate antiplasmodial activity.