MUCOSAL BLOOD-FLOW DURING VARIOUS INTRAVENOUS AND INHALATIONAL ANESTHETICS IN THE RABBIT

Objective, The goal of this study was to compare the effects of nitrou s oxide (N2O), isoflurane (ISO) fentanyl (FENT)I and propofol (PROP) o n the tongue mucosal blood flow (TMBF) in rabbits. Study design, TMBF was measured with a laser Doppler flow meter before and after the admi nistration of 50% N2O (n = 7), 1.0 and 1.5 minimum alveolar concentrat ion ISO (n = 6), 10, 20, and 40 mu g/kg FENT (n = 8) or 100, 200 and 4 00 mu g/kg/min PROP (n = 7). Hemodynamic variables including heart rat e, systolic blood pressure (SEP), mean arterial pressure (MAP) and aor tic blood flow (AoF) were continuously monitored. Total peripheral res istance (TPR) was calculated as MAP divided by AoF. Results, An increa se in TMBF along with reductions in SEP, MAP and TPR were observed in ISO group. In PENT group, TMBF was decreased, whereas other hemodynami c variables showed no change. TMBF in groups N2O and PROP did not chan ge, Conclusion, These results indicate that TMBF depends on the anesth etic used.