Q. Zhu et al., THE ROLE OF INTEGRIN BETA(1) IN HUMAN DENTAL-PULP CELL-ADHESION ON LAMININ AND FIBRONECTIN, Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 85(3), 1998, pp. 314-318
Citations number
19
Categorie Soggetti
Pathology,Surgery,"Dentistry,Oral Surgery & Medicine
Objective. This study is to identify the expression of integrin beta(1
) in human dental pulp cells and the role of integrin beta(1) in pulp
cell adhesion on extracellular matrix protein laminin and fibronectin.
Study design. Immunoblot detection of integrin beta(1) in human denta
l pulp cells was with the use of monoclonal anti-beta(1) antibody. Den
ial pulp cell adhesion assay on extracellular matrix protein laminin a
nd fibronectin and blocking cell adhesion was performed with monoclona
l anti-beta(1) antibody. Result. Integrin beta(1) was identified in hu
man dental pulp cells. Pulp cells adhered and spread on both laminin a
nd fibronectin. Monoclonal anti-beta(1) antibody inhibited human denta
l pulp cells adhesion on laminin but not on fibronectin. Conclusions,
Integrin beta(1) was expressed on human dental pulp cells and mediated
cell adhesion on laminin. Human denial pulp cells also adhered on fib
ronectin but the adhesion was not regulated by beta(1) integrin.