THE ROLE OF INTEGRIN BETA(1) IN HUMAN DENTAL-PULP CELL-ADHESION ON LAMININ AND FIBRONECTIN

Authors
ZHU Q SAFAVI KE SPANGBERG LSW
Citation
Q. Zhu et al., THE ROLE OF INTEGRIN BETA(1) IN HUMAN DENTAL-PULP CELL-ADHESION ON LAMININ AND FIBRONECTIN, Oral surgery, oral medicine, oral pathology, oral radiology and endodontics, 85(3), 1998, pp. 314-318
Citations number
19
Categorie Soggetti
Pathology,Surgery,"Dentistry,Oral Surgery & Medicine
Journal title
Oral surgery, oral medicine, oral pathology, oral radiology and endodontics → ACNP
ISSN journal
10792104
Volume
85
Issue
3
Year of publication
1998
Pages
314 - 318
Database
ISI
SICI code
1079-2104(1998)85:3<314:TROIBI>2.0.ZU;2-X
Abstract
Objective. This study is to identify the expression of integrin beta(1 ) in human dental pulp cells and the role of integrin beta(1) in pulp cell adhesion on extracellular matrix protein laminin and fibronectin. Study design. Immunoblot detection of integrin beta(1) in human denta l pulp cells was with the use of monoclonal anti-beta(1) antibody. Den ial pulp cell adhesion assay on extracellular matrix protein laminin a nd fibronectin and blocking cell adhesion was performed with monoclona l anti-beta(1) antibody. Result. Integrin beta(1) was identified in hu man dental pulp cells. Pulp cells adhered and spread on both laminin a nd fibronectin. Monoclonal anti-beta(1) antibody inhibited human denta l pulp cells adhesion on laminin but not on fibronectin. Conclusions, Integrin beta(1) was expressed on human dental pulp cells and mediated cell adhesion on laminin. Human denial pulp cells also adhered on fib ronectin but the adhesion was not regulated by beta(1) integrin.