EXPANSION OF HUMAN AUTOLOGOUS CYTOTOXIC T-LYMPHOCYTES ON FIXED TARGETTUMOR-CELLS

Authors
HORIUCHI K TSURUSHIMA H KIM BS LIU SQ SAIJO K SAIJO Y NUKIWA T NOMURA N MATSUMURA M OHNO T
Citation
K. Horiuchi et al., EXPANSION OF HUMAN AUTOLOGOUS CYTOTOXIC T-LYMPHOCYTES ON FIXED TARGETTUMOR-CELLS, Cytotechnology, 26(2), 1998, pp. 119-124
Citations number
12
Categorie Soggetti
Biothechnology & Applied Migrobiology","Cell Biology
Journal title
Cytotechnology → ACNP
ISSN journal
09209069
Volume
26
Issue
2
Year of publication
1998
Pages
119 - 124
Database
ISI
SICI code
0920-9069(1998)26:2<119:EOHACT>2.0.ZU;2-W
Abstract
Human tumor specific cytotoxic T lymphocytes (CTL) were expanded on fo rmalin-fixed autologous target tumor cells derived from glioblastoma m ultiforme. Growth response of the CTL restimulated with the fixed targ et cells was larger than those with live target cells. The results sug gest that formalin-fixed tumor cells will be stable sources of tumor a ntigen for efficient autologous CTL expansion and be useful for adopti ve immunotherapy of tumors.