Anorectal melanoma is a rare disease and, unlike cutaneous melanoma, t
here are few guidelines regarding optimal management. It has a reputat
ion for having a poor prognosis, which has been attributed to a delay
in diagnosis and to a lack of effective systemic therapy. It has also
been suggested that the biology of this tumor may differ from that of
cutaneous melanoma. An interesting ease of anorectal melanoma is prese
nted which highlights the unique considerations and challenges encount
ered by medical oncologists and surgeons who treat this disease.