Xp. Hao et al., EXPRESSION OF MDM2 AND P53 IN EPITHELIAL NEOPLASMS OF THE COLORECTUM, Journal of clinical pathology-Molecular pathology, 51(1), 1998, pp. 26-29
Aims-To evaluate the respective roles of mdm2 (murine double minute 2)
and p53 in the development of colorectal carcinoma. Methods-Formalin
fixed, paraffin wax embedded tissues from 72 sporadic adenomas and 55
carcinomas were investigated by means of immunohistochemistry for mdm2
and p53. Results-mdm2 was expressed weakly in 17 of 72 (23.6%) adenom
as and in 14 of 55 (25.4%) carcinomas. p53 was expressed in 19 of 72 (
26.4%) adenomas and in 23 of 55 (41.8%) carcinomas. Four adenomas and
five carcinomas showed positive staining for both proteins. Overexpres
sion of p53 in adenomas was associated with moderate and severe dyspla
sia but not with tumour size. No associations were found between the e
xpression of mdm2 and either the degree of dysplasia or tumour size. I
n carcinomas, neither the expression of p53 nor mdm2 correlated with D
ukes's stage, metastasis, or differentiation. No associations were fou
nd between the expression of p53 and mdma in either adenomas or carcin
omas. Conclusions-Although mdm2 has been reported to be an oncogene, i
t does not appear to play a major role in the development of colorecta
l carcinoma.