MICROSATELLITE INSTABILITY IN FEMALE NON-SMALL-CELL LUNG-CANCER PATIENTS WITH FAMILIAL CLUSTERING OF MALIGNANCY

Citation
K. Suzuki et al., MICROSATELLITE INSTABILITY IN FEMALE NON-SMALL-CELL LUNG-CANCER PATIENTS WITH FAMILIAL CLUSTERING OF MALIGNANCY, British Journal of Cancer, 77(6), 1998, pp. 1003-1008
Citations number
34
Categorie Soggetti
Oncology
Journal title
ISSN journal
00070920
Volume
77
Issue
6
Year of publication
1998
Pages
1003 - 1008
Database
ISI
SICI code
0007-0920(1998)77:6<1003:MIIFNL>2.0.ZU;2-#
Abstract
There is accumulating evidence of an increased risk of familial cluste ring of cancer in the first-degree relatives of lung cancer probands. However, no explanation has been proposed for these epidemiological da ta. We reviewed 379 female non-small-cell lung cancer (NSCLC) patients to obtain their family histories of malignancy. Among them, nine fema le NSCLC patients with three or more relatives diagnosed with malignan cy and 28 control patients without a family history of malignancy were selected to be analysed for instability at six different microsatelli te loci. We observed microsatellite instability (MSI) more frequently in the patients with three or more family histories of malignancy (six out of nine, 67%) than the control patients (5 out of 28, 18%). The i ncidence of MSI in the former was significantly higher than that in th e control (P = 0.011: Fisher's exact test). We detected no significant difference in clinicopathological characteristics between the cases w ith MSI and those without MSI, except for their family histories of ca ncer. Our results show that a significantly higher rate of MSI is asso ciated with familial clustering of malignancy. MSI could be one of the underlying mechanisms for familial clustering of malignancy in female NSCLC patients.