Clinical practice guidelines have enormous potential to improve the qu
ality of and accountability in health care, Making the most of this po
tential should become easier as guideline developers integrate guideli
nes within information systems and electronic medical records, A major
barrier to such integration is the lack of computing infrastructure i
n many clinical settings, To successfully implement guidelines in info
rmation systems, developers must create more specific recommendations
than those that have been required for traditional guidelines, Using r
eusable software components to create guidelines can make the developm
ent of protocols faster and less expensive, In addition, using decisio
n models to produce guidelines enables developers to structure guideli
ne problems systematically, to prioritize information acquisition, to
develop site-specific guidelines, and to evaluate the cost-effectivene
ss of the explicit incorporation of patient preferences into guideline
recommendations. Ongoing research provides a foundation for the use o
f guideline development tools that can help developers tailor guidelin
es appropriately to their practice settings, This article explores how
medical informatics can help clinicians find, use, and create practic
e guidelines.