IN-VITRO INTERACTION BETWEEN OFLOXACIN AND CEFOTAXIME AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA INVOLVED IN SERIOUS INFECTIONS

Authors
GIMENO C BORJA J NAVARRO D VALDES L GARCIABARBAL J GARCIADELOMAS J
Citation
C. Gimeno et al., IN-VITRO INTERACTION BETWEEN OFLOXACIN AND CEFOTAXIME AGAINST GRAM-POSITIVE AND GRAM-NEGATIVE BACTERIA INVOLVED IN SERIOUS INFECTIONS, Chemotherapy, 44(2), 1998, pp. 94-98
Citations number
16
Categorie Soggetti
Pharmacology & Pharmacy
Journal title
Chemotherapy → ACNP
ISSN journal
00093157
Volume
44
Issue
2
Year of publication
1998
Pages
94 - 98
Database
ISI
SICI code
0009-3157(1998)44:2<94:IIBOAC>2.0.ZU;2-H
Abstract
The checkerboard method was used to determine the antimicrobial activi ty of the combination cefotaxime/ofloxacin against 217 bacterial isola tes involved in serious infections. Synergy or partial synergy was obs erved against 19 of 34 (55.8%) Staphylococcus aureus methicillin-susce ptible isolates, 4 of 47 (8.4%) Streptococcus pneumoniae isolates, 28 of 34 (82.2%) Escherichia coli isolates and 70 of 102 (68.5%) Pseudomo nas aeruginosa isolates. Antagonism was not observed with any of the i solates examined.