F. Bonnet et al., CALCIUM-DEPENDENT LAW RENIN SYNDROME IN A DIABETIC PATIENT WITH PROSTAGLANDIN DEFICIENCY, Journal of endocrinological investigation, 21(1), 1998, pp. 64-66
Calcium and prostaglandin are supposed to play a critical role in the
renin-angiotensin aldosterone system. Calcium has been described as an
inhibitory second messenger for renin exocytosis whereas vasodilatory
prostaglandins, such as PGE(2), are known to stimulate the production
of renin. These factors are probably interrelated since calcium also
enhances urinary prostaglandin release. We report the case of a 52 yea
r-old diabetic patient treated with insulin injections with intestinal
malabsorption leading to chronic hyperkalemia and hypocalcemia in who
m a low renin syndrome and low levels of urinary prostaglandins were o
bserved. The correction of the hypocalcemia was able to improve plasma
renin as well as urinary prostaglandin levers. This observation sugge
sts a prominent role played by calcium on the in vivo regulation of re
nin and prostaglandin release. These results illustrate the closed loo
p between plasma calcium level, urinary prostaglandins production and
renin release. (C) 1998, Editrice Kurtis.