MECHANISMS OF THYROID-HORMONE ACTION - IMPLICATIONS FOR THE CLINICAL MANIFESTATION OF THYROTOXICOSIS

Authors
MOTOMURA K BRENT GA
Citation
K. Motomura et Ga. Brent, MECHANISMS OF THYROID-HORMONE ACTION - IMPLICATIONS FOR THE CLINICAL MANIFESTATION OF THYROTOXICOSIS, Endocrinology and metabolism clinics of North America, 27(1), 1998, pp. 1
Citations number
96
Categorie Soggetti
Endocrynology & Metabolism
Journal title
Endocrinology and metabolism clinics of North America → ACNP
ISSN journal
08898529
Volume
27
Issue
1
Year of publication
1998
Database
ISI
SICI code
0889-8529(1998)27:1<1:MOTA-I>2.0.ZU;2-D
Abstract
Thyroid hormone acts predominantly by combining with high affinity nuc lear receptors and modifying gene expression. There are two thyroid ho rmone receptor genes, alpha and beta, with multiple isoforms that are differentially expressed developmentally and in adult tissues. Thyroid hormone-regulated genes have been identified in a number of tissues, and their expression is altered in thyrotoxicosis. Correlations betwee n the clinical manifestations of thyrotoxicosis and modified gene expr ession can be made in some tissues.