This study examined the net effects of refining a high school-based in
dicated drug prevention program. The Personal Growth Class (PGC), tail
ored to meet the needs of high-risk youth, was designed to increase co
ntrol of drug use, school performance, and emotional well-being. The p
rogram integrates social support and life-skills training. Process eva
luation revealed the need for program enhancements to address underest
imated levels of depression, anger, and suicidal behaviors prevalent a
mong high-risk youth and to ensure that core content was being emphasi
zed consistently. Youth participating in Late cohorts received the ref
ined PGC with enhanced skills training. Study participants (N = 280) w
ere youth, primarily ages fifteen to seventeen, at high-risk for schoo
l failure or dropout. Indicators of emotional well-being (e.g., depres
sion, stress, anger, self-esteem, personal control), drug involvement,
and school performance were compared for Late versus Early cohorts. R
egression analyses revealed the Late versus Early cohorts showed signi
ficantly greater decreases in hard drug use, depression, perceived str
ess, and anger; and greater increases in self-esteem. The results supp
ort arguments that effective indicated prevention programs should targ
et specific high-risk youth employing strategies to counteract the mul
tifaceted risk factors they experience and enhance needed protective f
actors.