SYNTHESES OF HIGHLY OXYGEN-FUNCTIONALIZED DERIVATIVES OF DIHYDRODIHYDROXYPHTHALIC ACID IN ENANTIOMERICALLY ENRICHED FORMS

Authors
IKEDA H SUGAI T HOSOMI H OHBA S OHTA H
Citation
H. Ikeda et al., SYNTHESES OF HIGHLY OXYGEN-FUNCTIONALIZED DERIVATIVES OF DIHYDRODIHYDROXYPHTHALIC ACID IN ENANTIOMERICALLY ENRICHED FORMS, Bioscience, biotechnology, and biochemistry, 62(2), 1998, pp. 396-400
Citations number
18
Categorie Soggetti
Biology,Agriculture,"Biothechnology & Applied Migrobiology","Food Science & Tenology
Journal title
Bioscience, biotechnology, and biochemistry → ACNP
ISSN journal
09168451
Volume
62
Issue
2
Year of publication
1998
Pages
396 - 400
Database
ISI
SICI code
0916-8451(1998)62:2<396:SOHODO>2.0.ZU;2-Q
Abstract
Starting from dihydrodihydroxyphthalic acid (DDP), (1R, 2S, 5R, -8,8-d imethyl-6,8-dioxabicyclo[4.3.0]non-3-en-2-yl chloroacetate (>95%e.e.), a highly oxygen-functionalized derivative, was prepared by a combinat ion of chemical and enzymatic reactions. The hey step for asymmetrizat ion was hydrolysis of the corresponding meso bis-chloroacetate with pi g pancreatic lipase.