CELL KINETIC PATTERNS IN EARLY GASTRIC-CANCER

Early gastric cancers (EGC) may be subdivided into 2 groups by means o f the use of mitotic index, apoptotic index and cell density: EGCs wit h high cell turnover and low cell density, which show high cell dissoc iation and, more frequently, lymph node invasion; EGCs with low cell t urnover and high cell density. The same parameters discriminate among intestinal type tumors, when separately considered from diffuse ones. No correlation is noted of these 2 groups with transforming growth fac tor-alpha, epidermal growth factor receptor and p53 expression, gross type, entity of neoangiogenesis, and submucosal invasion.