6 NOVEL MUTATIONS IN THE NF2 TUMOR-SUPPRESSOR GENE

Six novel mutations were identified in the NF2 tumor suppressor gene i n a panel of meningiomas and neurinomas. Screening was performed using a combination of single-strand conformation polymorphism and heterodu plex analyses on polymerase chain reaction-amplified DNA from tumors a nd matched peripheral blood lymphocytes. Mutations involved exons 2, 7 , 11 and 12, and corresponded to three frameshift, one nonsense, one m issense and one polymorphism.