MELANIN BIOSYNTHESIS IN CRYPTOCOCCUS-NEOFORMANS

Authors
WILLIAMSON PR WAKAMATSU K ITO S
Citation
Pr. Williamson et al., MELANIN BIOSYNTHESIS IN CRYPTOCOCCUS-NEOFORMANS, Journal of bacteriology, 180(6), 1998, pp. 1570-1572
Citations number
20
Categorie Soggetti
Microbiology
Journal title
Journal of bacteriology → ACNP
ISSN journal
00219193
Volume
180
Issue
6
Year of publication
1998
Pages
1570 - 1572
Database
ISI
SICI code
0021-9193(1998)180:6<1570:MBIC>2.0.ZU;2-T
Abstract
Pigment production by Cryptococcus neoformans is virulence associated. Dopamine-and 3,4 dihydroxyphenylalanine-melanin products were identif ied after acidic permanganate oxidation, alkaline hydrogen peroxide ox idation, or hydrolysis with hydriodic acid. These data provide direct chemical evidence for the formation of eumelanin Polymers by catechola mine oxidation by laccase alone followed by oxidative coupling of dihy droxyindole.