AGE-RELATED-CHANGES IN THE CEREBROSPINAL-FLUID LEVEL OF BETA-ENDORPHIN AND SUBSTANCE-P - SHORT COMMUNICATION

Authors
NAGAMITSU S MATSUISHI T KOMORI H YAMASHITA Y EGUCHI H ICHIKAWA K FUJIMOTO T KATO H
Citation
S. Nagamitsu et al., AGE-RELATED-CHANGES IN THE CEREBROSPINAL-FLUID LEVEL OF BETA-ENDORPHIN AND SUBSTANCE-P - SHORT COMMUNICATION, Journal of neural transmission, 105(1), 1998, pp. 53-58
Citations number
20
Categorie Soggetti
Clinical Neurology",Neurosciences
Journal title
Journal of neural transmission → ACNP
ISSN journal
03009564
Volume
105
Issue
1
Year of publication
1998
Pages
53 - 58
Database
ISI
SICI code
0300-9564(1998)105:1<53:AITCLO>2.0.ZU;2-9
Abstract
To evaluate the early age-related changes in neuropeptides, we have me asured the cerebrospinal fluid (CSF) levels of beta-endorphin and subs tance P in young patients over a range of ages. Specimens of CSF were obtained from 39 neurologically normal children, aged 1 month to 10 ye ars of age, and in 9 adult controls. CSF levels of both neuropeptides were observed to peak during the first year of life, and showed a nega tive correlation with increasing age. A significant positive correlati on was observed between the CSF level of beta-endorphin and that of su bstance P.