To test the hypothesis that occupational lifting is a cause of hip ost
eoarthritis, the authors examined associations with lifting and other
occupational activities in a case-control study, The study was perform
ed in two English health districts (Portsmouth and North Staffordshire
) from 1993 to 1995. A total of 611 patients (210 men and 401 women) l
isted for hip replacement because of osteoarthritis over an 18-month p
eriod were compared with an equal number of controls selected from the
general population and individually matched for age, sex, and general
practice. Information about suspected risk factors was obtained by a
questionnaire administered at interview and a short physical examinati
on, Analysis was by conditional logistic regression, After adjustment
for potential confounders, the risk in men increased progressively wit
h the duration and heaviness of occupational lifting, Relative to thos
e with low exposure, men who had regularly lifted weights in excess of
50 kg for 10 years or longer had an odds ratio of 3.2 (95% confidence
interval 1.6-6.5), No comparable association was found in women, Of t
he other occupational activities examined, only frequent climbing of s
tairs showed a pattern suggestive of a causal relation, These findings
are consistent with the results of other studies, and there is now a
strong case for regarding hip osteoarthritis as an occupational diseas
e in men whose work has involved prolonged and frequent heavy lifting.