NUTRIENT CONSUMPTION AND METABOLIC PERTURBATIONS

The brain is entirely dependent on a continual supply of nutrients for the production of energy and the maintenance of function. Brain attac k is a good example of a condition where the loss of blood flow and th e consequent deprivation of nutrients can be devastating in terms of b oth structure and function. The unique metabolic characteristics of th e brain make it more susceptible than most other organs of the body to nutrient restriction and starvation. In addition, changes occur durin g ischemia that compromise nutrient consumption even with reperfusion. Clearly, improving the outcome following brain attack will require a restoration of nutrient consumption to meet the relatively high energe tic demands of the brain, and novel interventions to offset any metabo lic lesions induced by the insult or reperfusion injury.