We present a case of facial pain associated with sweet stimulus. An im
mediate, electriclike, short, unilateral pain was evoked by strong swe
et gustatory stimulation. This was followed 6 to 8 hours later by a bi
lateral severe headache associated with bilateral tearing, rhinorrhea,
periorbital swelling, flushing, and photophobia that lasted up to 2 d
ays. The immediate pain that was experimentally induced with 2.5 grams
of sucrose placed on the tongue could be abolished with carbamazepine
. However, carbamazepine did not prevent the headache complex that app
eared 6 to 8 hours later. Conversely, a trial with indomethacin abolis
hed the late-onset headache, but not the immediate neuralgic-type pain
. The independent nature of these pains suggests different pathophysio
logical mechanisms which are discussed.