Distinguishing malignancy from premalignant conditions can be difficul
t. Controversy surrounds both the clinical and histologic criteria use
d to distinguish lymphomatoid papulosis, a benign disorder, from CD30(
+) anaplastic large-cell lymphoma. Three case histories illustrate imp
ortant points in categorizing different lymphoproliferative disorders
as benign or malignant, We emphasize a multidisciplinary approach to i
mprove diagnosis and patient management.