Irrational and inconsistent drug prescription has considerable impact
on morbidity, mortality, health service utilization, and community bur
den, However, few studies have addressed the methodology of processing
the information contained in these drug orders used to study the qual
ity of drug prescriptions and prescriber behavior. We present a compre
hensive set of quantitative indicators for the quality of drug prescri
ptions which can be derived from a drug order. These indicators were c
onstructed using explicit a priori criteria which were previously vali
dated on the basis of scientific data, Automatic computation is straig
htforward, using a relational database system, such that large sets of
prescriptions can be processed with minimal human effort. We illustra
te the feasibility and Value of this approach by using a large set of
23,000 prescriptions for several diseases, selected from a nationally
representative prescriptions database. Our study may result in direct
and wide applications in the epidemiology of medical practice and in q
uality control procedures.