BETA-LACTAMASE INHIBITORS FROM THE SULBAC TAM CLASS - I - STUDIES ON THE SULBACTAM SYNTHESIS WAYS

Citation
C. Vlase et al., BETA-LACTAMASE INHIBITORS FROM THE SULBAC TAM CLASS - I - STUDIES ON THE SULBACTAM SYNTHESIS WAYS, Revista de chimie, 49(2), 1998, pp. 96-101
Citations number
8
Categorie Soggetti
Engineering, Chemical",Chemistry
Journal title
ISSN journal
00347752
Volume
49
Issue
2
Year of publication
1998
Pages
96 - 101
Database
ISI
SICI code
0034-7752(1998)49:2<96:BIFTST>2.0.ZU;2-J
Abstract
The experimental studies worked our in order to get an optimum method for the sodium sulbactam synthesis, i.e. a beta-lactamase inhibitor wi dely used in bacterial infections therapy is presented. Two this end t he sodium sulbactam synthesis was tested in two variants using the 6-a mino-penicillanic acid and penicillin G, respectively, as row material s. The experimetal results showed As the optimum variant the synthesis from the 6-amino pencillanic acid; this is the procedure the reaction conditions to obtain the maximum yields and high purity for the inter mediates involved in the synthesis and, implicitely, a low cost for th e sodium sulbactam, of a corresponding quality to the International Ph armacopoeas, were set for.