BETA-LACTAMASE INHIBITORS FROM THE SULBAC TAM CLASS - I - STUDIES ON THE SULBACTAM SYNTHESIS WAYS

The experimental studies worked our in order to get an optimum method for the sodium sulbactam synthesis, i.e. a beta-lactamase inhibitor wi dely used in bacterial infections therapy is presented. Two this end t he sodium sulbactam synthesis was tested in two variants using the 6-a mino-penicillanic acid and penicillin G, respectively, as row material s. The experimetal results showed As the optimum variant the synthesis from the 6-amino pencillanic acid; this is the procedure the reaction conditions to obtain the maximum yields and high purity for the inter mediates involved in the synthesis and, implicitely, a low cost for th e sodium sulbactam, of a corresponding quality to the International Ph armacopoeas, were set for.