LEUKEMOID MONOCYTOSIS IN M4 AML FOLLOWING CHEMOTHERAPY AND G-CSF

We describe a patient with M4 AML treated with standard chemotherapy f ollowed by G-CSF who developed marked monocytosis on day 8 of G-CSF th erapy. Fourteen days after discontinuation of G-CSF therapy his monocy te counts returned to normal levels and a marrow aspirate showed a red uction in blast cells. He received further chemotherapy without G-CSF and without any recurrence of the raised leucocyte count but failed to achieve full remission, Although this G-CSF-driven leucocytosis was a larming it did not appear to have adversely affected the patient's pro gnosis.