Objective: To determine if the medial brow can be elevated following a
dministration of botulinum toxin type A (Botox, Allergan, Irvine, Cali
f). Design: A before-after interventional study comparing pretreatment
and posttreatment brow height. Objective measurements and subjective
comparisons of pretreatment and posttreatment slides were made by 7 in
dependent observers unaware of treatment status. All measurements and
observations were based on standardized photographs taken with identic
al lens settings. Setting: Private facial plastic surgery practice. Al
l injections were performed in office examination rooms without anesth
esia or sedation. Patients: Thirty adult patients electively seeking i
mprovement of glabellar frown lines or low-positioned medial brews (an
gry appearance). Intervention: Twenty units of botulinum toxin type A
was injected into the corrugator supercilli and procerus muscles. An e
lectromyographic needle was used for the initial 10 injections, and a
30-gauge needle was used for the remainder. Outcome Measures: In the o
bjective arm, change in brow height was measured from the medial canth
us and midpupil directly vertical to the brow hairs; the change in int
erbrow distance was also measured. In the subjective arm, the number o
f patients who were found to have an elevated medial brow by the indep
endent observers was noted. Objective and subjective findings were cor
related. Results: Objective measurements yielded a raise in the medial
brow in 8 (32%) of 25 patients from the medial canthus and in 12 (48%
) of 25 from the midpupil and an increase in interbrow distance in 17
(59%) of 29 patients. Subjective comparison found 18 (62%) of the 29 p
atients to have higher medial brews after treatment. Conclusions: Botu
linum toxin type A treatment can create a chemical browlift. Further s
tudies with more specific selection criteria are needed to better eval
uate this effect.