Co. Okere et al., PERIVASCULAR LOCALIZATION OF NITRIC-OXIDE SYNTHASE IN THE RAT ADENOHYPOPHYSIS - POTENTIAL IMPLICATIONS FOR FUNCTION AND CELL-CELL INTERACTION, Brain research, 784(1-2), 1998, pp. 337-340
The possible localization of nitric oxide (NO) synthase (NOS) in proxi
mity to the microvasculature was examined in the rat adenohypophysis u
sing immunohistochemistry and nicotinamide adenine dinucleotide phosph
ate diaphorase histochemistry. A population of NOS-positive cells was
localized in very close contact with the sinusoidal capillaries. The p
attern of this perivascular localization was either unicellular, bicel
lular or multicellular. These observations suggest that, at least, som
e actions of NO in the adenohypophysis can be accounted for by a local
regulation of the glandular microvasculature. (C) 1998 Elsevier Scien
ce B.V.