THE DISPOSITION KINETICS, URINARY-EXCRETION AND DOSAGE REGIMEN OF AMIKACIN IN CROSSBRED BOVINE CALVES

The disposition kinetics, urinary excretion and dosage regimen of amik acin after a single intravenous administration of 10 mg/kg was investi gated in six cross-bred bovine calves. At 1 min, the concentration of amikacin in the plasma was 116.9+/-3.16 mu g/ml and the minimum therap eutic concentration was maintained for 8 h. The elimination half-life and volume of distribution were 3.09+/-0.27 h and 0.4+/-0.03 L/kg, res pectively. The total body clearance (Cl-B) and T/P ratio were 0.09+/-0 .002 L/kg/h and 4.98+/-0.41, respectively. Approximately 50% of the to tal dose of amikacin was recovered in the urine within 24 h after admi nistration. Amikacin in concentrations ranging from 5 to 150 mu g/ml b ound to plasma proteins to the extent of 6.32%+/-0.42%. A satisfactory intravenous dosage regimen of amikacin in bovine calves would be 13 m g/kg followed by 12 mg/kg at 12 h intervals.