HUMAN PLATELETS CONTAIN A NOVEL 47 KDA THIOL-OXIDASE HAVING AFFINITY FOR GENOMIC STEROL-REGULATORY SEQUENCE

Authors
KAUL D KAUR M DHAWAN V
Citation
D. Kaul et al., HUMAN PLATELETS CONTAIN A NOVEL 47 KDA THIOL-OXIDASE HAVING AFFINITY FOR GENOMIC STEROL-REGULATORY SEQUENCE, Molecular and cellular biochemistry, 178(1-2), 1998, pp. 383-385
Citations number
8
Categorie Soggetti
Biology,"Cell Biology
Journal title
Molecular and cellular biochemistry → ACNP
ISSN journal
03008177
Volume
178
Issue
1-2
Year of publication
1998
Pages
383 - 385
Database
ISI
SICI code
0300-8177(1998)178:1-2<383:HPCAN4>2.0.ZU;2-8
Abstract
The present study provides evidence to support that human platelets po ssess a 47 kDa dual functional molecule having thioloxidase activity a s well as high affinity for the SRE sequence in the human genome. On t he basis of these as well as earlier results, we propose that Receptor 'C-k' dependent regulation of this dual functional 47 kDa molecule ma y provide a mechanism for the maintenance of cellular cholesterol home ostasis. Further, this mechanism may also explain the molecular basis of cholesterol-feedback lesion observed under premalignant conditions.