MICROBICIDAL EFFECTIVENESS OF POVIDONE-IO DINE (BETAISODONA(R)) AGAINST HIGHLY RESISTANT GRAM POSITIVES

Antiseptics that are locally applicable gain in significance due to th eir reliable microbicidal effectiveness and especially due to the risi ng incidence of highly resistant bacteria. This is because systemicall y applied antibiotics are not sufficient in eradicating superficial mu codermal bacteria and locally applied antibiotics can cause new resist ance rapidly. The aim of this study was to demonstrate the microbicida l effectiveness of Poly(1-vinyl-2-pyrrolidon)-iodine (PVP-iodine) agai nst ten genotypical different methicillin resistant Staphylococcus aur eus-(MRSA-) and five Enterococcus faecium-strains in a quantitative su spension test. The effectiveness of PVP-iodine with protein load (0.2% and 2% albumin) was tested against three MRSA strains. Without any pr otein load best microbicidial activity (KRt-value >5) was obtained wit h concentrations in the range between 1-10% of the original Betaisodon a(R) solution after 30s exposure time. With protein load (0.2% albumin ) the optimum in microbicidal effectiveness shifts to concentrations g reater than or equal to 10% Betaisodona(R) solution referring to an ex posure time of 30 s. With a protein load up to 2% albumin and an expos ure time of 30 s the bactericidal activity of the undiluted Betaisodon a(R) solution is already satisfying, while the 10% solution is not act ive till an exposure time of 5 min. Summing up PVP-iodine is recommend ed as a local mucodermal antiseptic against highly resistant gram posi tives.