USE OF CONTROLLED-PORE GLASS IN SOLID-PHASE OLIGOSACCHARIDE SYNTHESIS- APPLICATION TO THE SEMIAUTOMATED SYNTHESIS OF A GLYCONUCLEOTIDE CONJUGATE

Authors
ADINOLFI M BARONE G DENAPOLI L IADONISI A PICCIALLI G
Citation
M. Adinolfi et al., USE OF CONTROLLED-PORE GLASS IN SOLID-PHASE OLIGOSACCHARIDE SYNTHESIS- APPLICATION TO THE SEMIAUTOMATED SYNTHESIS OF A GLYCONUCLEOTIDE CONJUGATE, Tetrahedron letters, 39(14), 1998, pp. 1953-1956
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
14
Year of publication
1998
Pages
1953 - 1956
Database
ISI
SICI code
0040-4039(1998)39:14<1953:UOCGIS>2.0.ZU;2-D
Abstract
Three polymeric supports (polystyrene, Tentagel and controlled pore gl ass) have been tested for solid phase synthesis of oligosaccharides ba sed on the trichloroacetimidate methodology, Controlled pore glass has been found to yield satisfactory results with TMSOTf as the glycosyla tion promoter. An application to the on-line preparation of a glyconuc leotide is also reported. (C) 1998 Elsevier Science Ltd. All rights re served.