HETEROLIGNANOLIDES - SYNTHESIS OF A NEW FAMILY OF THIENOLIGNANOLIDES

Authors
MEDARDE M RAMOS AC CABALLERO E LOPEZ JL DECLAIRAC RPL SANFELICIANO A
Citation
M. Medarde et al., HETEROLIGNANOLIDES - SYNTHESIS OF A NEW FAMILY OF THIENOLIGNANOLIDES, Tetrahedron letters, 39(14), 1998, pp. 2001-2004
Citations number
31
Categorie Soggetti
Chemistry Inorganic & Nuclear
Journal title
Tetrahedron letters → ACNP
ISSN journal
00404039
Volume
39
Issue
14
Year of publication
1998
Pages
2001 - 2004
Database
ISI
SICI code
0040-4039(1998)39:14<2001:H-SOAN>2.0.ZU;2-X
Abstract
A new family of thienolignanolides has been synthesized by means of co njugate addition-alkylation of 5H-furan-2-one, followed by cyclization and controlled epimerizations. The applicability of this versatile me thodology is extended to the preparation of heteroaromatic analogues o f biologically relevant cyclolignanolides. (C) 1998 Elsevier Science L td. All rights reserved.