PHOSPHOINOSITIDE METABOLISM AND CA2+ OSCILLATION

The main pathways of hydrolysis and synthesis of phosphoinositides, me tabolism of inositol phosphates and their role in animal and human cel ls are reviewed, Mechanisms of regulation of phospholipase C and other key enzymes of phosphoinositide metabolism by hormones and growth fac tors are discussed. The mechanisms of regulation of metabolism and cel lular activity by second messengers formed during activation of phosph oinositide hydrolysis are considered. Special attention is given to th e regulation of cytoplasmic Ca2+ level by inositol phosphates. The rev iew summarizes data on formation and possible biological role of inosi tol phosphates and phosphoinositides containing phosphate at position 3. The role of phosphoinositides in the interaction of cellular membra nes with proteins of the cytoskeleton is considered.