SYNTHESIS OF 2-ALKYNYLCORDYCEPINS AND EVALUATION OF THEIR VASODILATING ACTIVITY

Authors
KUMAMOTO H HAYAKAWA H TANAKA H SHINDOH S KATO K MIYASAKA T ENDO K MACHIDA H MATSUDA A
Citation
H. Kumamoto et al., SYNTHESIS OF 2-ALKYNYLCORDYCEPINS AND EVALUATION OF THEIR VASODILATING ACTIVITY, Nucleosides & nucleotides, 17(1-3), 1998, pp. 15-27
Citations number
25
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
1-3
Year of publication
1998
Pages
15 - 27
Database
ISI
SICI code
0732-8311(1998)17:1-3<15:SO2AEO>2.0.ZU;2-E
Abstract
Based on the recently developed lithiation-mediated stannyl migration of 6-chloropurine derivatives, 2-iodocordycepin was prepared from cord ycepin. The reaction of this compound with terminal alkynes was carrie d out to synthesize a series of 2-alkynyl derivatives. The vasodilatin g effect of these compounds was evaluated.