SYNTHESIS OF CHIRALLY PURE ORNITHINE BASED PNA ANALOGS

A stereoselective synthesis of a chiral PNA analogue containing an orn ithine based backbone is described. In this approach each elongation c ycle consists of two individual coupling steps: i.e. extension of the free delta-amino function in the growing chain by a TOPPipU mediated c oupling with Fmoc-Om(Boc)-OH, and subsequent acylation of a free alpha -amine with thymin-1-ylacetic acid. Thyminyl decamers were prepared fo llowing this strategy and hybridization experiments indicated that the y formed stable complexes with cRNA.