BIOLOGICALLY-ACTIVE OLIGODEOXYRIBONUCLEOTIDES - 10 - ANTI-HIV-1 ACTIVITY AND STABILITY OF MODIFIED HEXANUCLEOTIDES CONTAINING GLYCEROL-SKELETON

Authors
HOTODA H KOIZUMI M OHMINE T FURUKAWA H NISHIGAKI T ABE K KOSAKA T TSUTSUMI S SONE J KANEKO M KIMURA S SHIMADA K
Citation
H. Hotoda et al., BIOLOGICALLY-ACTIVE OLIGODEOXYRIBONUCLEOTIDES - 10 - ANTI-HIV-1 ACTIVITY AND STABILITY OF MODIFIED HEXANUCLEOTIDES CONTAINING GLYCEROL-SKELETON, Nucleosides & nucleotides, 17(1-3), 1998, pp. 243-252
Citations number
13
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
1-3
Year of publication
1998
Pages
243 - 252
Database
ISI
SICI code
0732-8311(1998)17:1-3<243:BO-1-A>2.0.ZU;2-N
Abstract
Deoxyribose-moieties of modified hexadeoxyribonucleotide 1, which part ially replaced with glycerol moieties. Compound 7 with two glycerylgua nines at its 3'-end showed more potent anti-HIV-1 activity and more st ability against digestion by nucleases than the parent compound 1.