PREPARATION OF STEREOREGULATED ANTISENSE OLIGODEOXYRIBONUCLEOSIDE PHOSHOROTHIOATE AND INTERACTION WITH ITS COMPLEMENTARY-DNA AND RNA

Authors
TAMURA Y MIYOSHI H YOKOTA T MAKINO K MURAKAMI A
Citation
Y. Tamura et al., PREPARATION OF STEREOREGULATED ANTISENSE OLIGODEOXYRIBONUCLEOSIDE PHOSHOROTHIOATE AND INTERACTION WITH ITS COMPLEMENTARY-DNA AND RNA, Nucleosides & nucleotides, 17(1-3), 1998, pp. 269-282
Citations number
50
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
1-3
Year of publication
1998
Pages
269 - 282
Database
ISI
SICI code
0732-8311(1998)17:1-3<269:POSAOP>2.0.ZU;2-J
Abstract
Diastereoisomeric specificity of oligodeoxyribonucleoside phosphorothi oate (OPT) in DNA/OPT and RNA/OPT hybrid formation was investigated. T he difference in the configuration between RRRR and SSSS was reflected in the conformation and the stability of the DNA/OPT and RNA/OPT hybr ids. Therefore, findings of this report rationalize the antisense effe ct by non-stereoregulated OPT and the difference of diastereoisomerism in susceptibility to RNase H.