PREPARATION OF AN OCTADEOXYRIBONUCLEOSIDE HEPTAPHOSPHOROTHIOATE BY THE PHOSPHOTRIESTER APPROACH IN SOLUTION

Authors
REESE CB SONG QL RAO MV BECKETT I
Citation
Cb. Reese et al., PREPARATION OF AN OCTADEOXYRIBONUCLEOSIDE HEPTAPHOSPHOROTHIOATE BY THE PHOSPHOTRIESTER APPROACH IN SOLUTION, Nucleosides & nucleotides, 17(1-3), 1998, pp. 451-470
Citations number
22
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
1-3
Year of publication
1998
Pages
451 - 470
Database
ISI
SICI code
0732-8311(1998)17:1-3<451:POAOHB>2.0.ZU;2-G
Abstract
The synthesis of the octadeoxyribonucleoside heptaphosphorothioate, d[ Tp(s)Tp(s)Gp(s)Gp(s)Gp(s)Gp(s)Tp(s)T] by the phosphotriester approach in solution is described. The phosphorothioate internucleotide linkage s are protected by the S-(2-cyanoethyl) group and -(mesitylene-2-sulfo nyl)-3-nitro-1,2,4-1H-triazole (MSNT) is used as the coupling agent. A block synthesis strategy (2 + 2 --> 4 and 4 + 4 --> 8) is followed.