STEREOSPECIFICITY OF 6'-C-NEPLANOCIN-A ANALOGS AS INHIBITORS OF S-ADENOSYLHOMOCYSTEINE HYDROLASE ACTIVITY AND HUMAN-IMMUNODEFICIENCY-VIRUS REPLICATION

The R-and S-isomers of 6'-C-neplanocin A analogues, which are all know n as inhibitors of S-adenosylhomocysteine (AdoHcy) hydrolase, were stu died for their inhibitory effects on Human Immunodeficiency Virus type 1 (HIV-1) replication and HIV-1 Tat-mediated transactivation. The R-i somers showed much greater activity against AdoHcy hydrolase than the S-isomers. The same differential activity was observed against the HIV -1 replication and the Tat transactivation.