SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES - 40 - SELECTIVE-INHIBITION OF EUKARYOTIC DNA POLYMERASE-ALPHA BY TA-D-ARABINOFURANOSYL)-2-(P-N-BUTYLANILINO)ADENINE 5'-TRIPHOSPHATE (BUAARAATP) AND ITS 2'-UP AZIDO ANALOG- SYNTHESIS AND ENZYMATIC EVALUATIONS

Authors
TOMIKAWA A SENO M SATOKIYOTAKI K OHTSUKI C HIRAI T YAMAGUCHI T KAWAGUCHI T YOSHIDA S SANEYOSHI M
Citation
A. Tomikawa et al., SYNTHETIC NUCLEOSIDES AND NUCLEOTIDES - 40 - SELECTIVE-INHIBITION OF EUKARYOTIC DNA POLYMERASE-ALPHA BY TA-D-ARABINOFURANOSYL)-2-(P-N-BUTYLANILINO)ADENINE 5'-TRIPHOSPHATE (BUAARAATP) AND ITS 2'-UP AZIDO ANALOG- SYNTHESIS AND ENZYMATIC EVALUATIONS, Nucleosides & nucleotides, 17(1-3), 1998, pp. 487-501
Citations number
28
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
1-3
Year of publication
1998
Pages
487 - 501
Database
ISI
SICI code
0732-8311(1998)17:1-3<487:SNAN-4>2.0.ZU;2-6
Abstract
Starting from 2',3',5'-tri-O-acetyl-2-iodoadenosine, ta-D-arabinofuran osyl)-2-(p-n-butylanilino)adenine and its 2'(S)-azido counterparts wer e synthesized in seven steps. These exhibited only moderate growth-inh ibitory effects against mouse leukemic P388 cells (IC50 = 13-24 mu M), although 5'-triphosphate derivatives showed strong and selective inhi bitory action on calf thymus DNA polymerase alpha, but not on beta- an d epsilon-polymerases from eukaryotes.