CHARACTERIZATION OF TELOMERIC OLIGONUCLEOTIDES - FIDELITY OF REPETITIVE NUCLEOTIDE-SEQUENCES

Authors
SHIDA T SUDA M SEKIGUCHI J
Citation
T. Shida et al., CHARACTERIZATION OF TELOMERIC OLIGONUCLEOTIDES - FIDELITY OF REPETITIVE NUCLEOTIDE-SEQUENCES, Nucleosides & nucleotides, 17(1-3), 1998, pp. 575-584
Citations number
18
Categorie Soggetti
Biology
Journal title
Nucleosides & nucleotides → ACNP
ISSN journal
07328311
Volume
17
Issue
1-3
Year of publication
1998
Pages
575 - 584
Database
ISI
SICI code
0732-8311(1998)17:1-3<575:COTO-F>2.0.ZU;2-5
Abstract
To clarify the reasons for the high fidelity of repetitive telomeric s equences, a series of d(TTXGGG)(4) (X: A, G, C, and T) were synthesize d and characterized by UV absorption, CD, chemical modification, and r esistance to nucleases. d(TTCGGG)(4), which is lacking in nature, has similar structural stability and resistance to nucleases, compared wit h d(TTAGGG)(4), which is widely present at the telomeres of many organ isms. d(TTGGGG)(4) is the most stable as a result of formation of the four G-quartet layers in the presence of potassium ion.