ASSOCIATION OF MYELODYSPLASTIC CHANGES WITH PURINE ANALOGS

We describe the occurrence of myelodysplastic changes (hypogranular my eloid series and Pelger cells, dyserythropoiesis with ring sideroblast s) in five of 31 patients with chronic lymphoproliferative disorders a fter treatment with purine analogues, The bone marrows of 31 patients with chronic lymphoproliferative disorders before and after treatment with purine analogues were reviewed, The majority of patients had rece ived extensive prior treatment, but none had dysplastic changes prior to treatment with purine analogues. We suggest that a purine analogue may have been responsible for dysplastic change and that further follo w-up of this phenomenon is warranted.