BLEEDING SYMPTOMS IN 27 IRANIAN PATIENTS WITH THE COMBINED DEFICIENCYOF FACTOR-V AND FACTOR-VIII

Inherited deficiency of factors V and VIII is the most frequent combin ed coagulation defect, The cases reported so far are mostly single cas es or small series from different centres, making it difficult to eval uate the overall pattern of clinical manifestations of the combined de fect. We examined at a single institution 27 Iranian patients. Mucocut aneous and post-surgical bleeding were the most frequent clinical mani festations. The presence of two defects did not make the severity of b reeding greater than that expected in patients with single coagulation defects of similar degrees.