NONINVASIVE INVESTIGATION OF ENDOTHELIUM-DEPENDENT DILATATION OF THE BRACHIAL-ARTERY IN WOMEN WITH PRIMARY RAYNAUDS-PHENOMENON

1, Primary Raynaud's phenomenon is characterized by white fingers and toes with impaired perfusion in response to cold or emotional stress, The aetiology has not been clarified, In previous studies we have demo nstrated a season-linked inability in women with primary Raynaud's phe nomenon to raise their plasma cGMP levels in response to whole-body co oling, suggesting a dysfunction of the L-arginine-NO-cGMP pathway, To further elucidate the possibility of such a defect in patients with pr imary Raynaud's phenomenon, we determined flow-mediated dilatation of the brachial artery, 2. Twenty-two premenopausal, non-smoking women wi th primary Raynaud's phenomenon (mean age 39+/-8 years) and 23 healthy controls (mean age 41+/-7 years) were studied during two winter weeks , The diameter of the right arm brachial artery was measured by high r esolution ultrasonography, at rest and during reactive hyperaemia, The investigation was conducted both with the participants at rest at roo m temperature and after 40 min of whole-body cooling, 3, Both study gr oups showed a marked attenuation of flow-mediated dilatation during wh ole-body cooling, which could partly but not solely be explained by a decreased shear rate, There was, however, no significant difference in flow-mediated diameter (D) increase (% flow-mediated dilatation; Delt a D/D x 100) between primary Raynaud's phenomenon and controls, either at room temperature (7.8+/-0.8 and 9,0+/-0,8) or in response to whole -body cooling (3.8+/-1.2 and 4.4+/-0.7), 4, Thus, whole-body cooling m arkedly impairs flow-mediated dilatation in women, Flow-mediated dilat ation is, however, not decreased in women with primary Raynaud's pheno menon at room temperature or during whole-body cooling, indicating tha t this particular aspect of endothelial function is not impaired in th is setting.