Pheohyphomycoses are an uncommon diverse group of dematiaceous fungi p
resent in soil and plant material and are potential pathogens. We repo
rt the case of a 45-year-old white Hispanic woman who presented with a
hard round cyst on the dorsum of her right foot caused by a traumatic
implantation of a piece of wood thirty-five years earlier. The cyst w
as surgically excised and the patient empirically treated with a two-m
onth course of oral itraconazole. To our knowledge, this represents a
case of the longest-lived asymptomatic pheohyphomycotic cyst in an imm
unocompetent person ever reported. The clinical manifestations, treatm
ent options, and disease course are reviewed.