Two feet-one hand syndrome is also defined as bilateral plantar tinea
pedis with coexistent unilateral tinea manuum, Toenails and fingernail
s may also be affected and the dermatophyte Trichophyton rubrum is the
usual cause, When there is nail involvement, especially of the toenai
ls, treatment with an oral antifungal agent should be considered becau
se topical therapy alone is usually not effective, However, relapses a
re common, With the advent of new, more effective antifungal drugs suc
h as itraconazole, terbinafine, and fluconazole, it is hoped that this
troublesome and recalcitrant disorder may be better controlled.