A case of a single molluscum contagiosum occurring on the surface of a
preexisting soft fibroma in an adult patient is reported. The most co
mmon clinical form of this viral lesion is multiple grouping papules w
ith a central umbilication and its histologic feature is characteristi
c. Previous cases of mollusca combining with other lesions have been r
arely described. Our lesion was probably due to its localization on th
e soft fibroma, whose exophytic growing represented a favoring factor
for trauma and the consequent occurrence of the viral disease.