SYNTHESIS OF PHENOXYACETIC ACID-DERIVATIVES AS HIGHLY POTENT ANTAGONISTS OF GASTRIN CHOLECYSTOKININ-B RECEPTORS/

Authors
TAKEDA Y KAWAGOE K YOKOMIZO A YOKOMIZO Y HOSOKAMI T OGIHARA Y HONDA Y YOKOHAMA S
Citation
Y. Takeda et al., SYNTHESIS OF PHENOXYACETIC ACID-DERIVATIVES AS HIGHLY POTENT ANTAGONISTS OF GASTRIN CHOLECYSTOKININ-B RECEPTORS/, Chemical and Pharmaceutical Bulletin, 46(3), 1998, pp. 434-444
Citations number
18
Categorie Soggetti
Chemistry Medicinal",Chemistry,"Pharmacology & Pharmacy
Journal title
Chemical and Pharmaceutical Bulletin → ACNP
ISSN journal
00092363
Volume
46
Issue
3
Year of publication
1998
Pages
434 - 444
Database
ISI
SICI code
0009-2363(1998)46:3<434:SOPAAH>2.0.ZU;2-Q
Abstract
A novel series of phenoxyacetic acid derivatives was synthesized based on considerations of the three-dimensional structural similarity of Y M022 and RP72540, The gastrin/cholecystokinin (CCK)-B and CCK-A recept or antagonist activities of these compounds were evaluated by investig ation of their affinities for human gastrin/CCK-B receptors and human CCK-A receptors, respectively. It was found that methylphenyl)ureido]a cetyl]amino]phenoxy]acetamide (20k, DZ-3514) exhibited high affinity f or gastrin/CCK-B receptors and high selectivity over CCK-A receptors.