DO NOTTINGHAM HEALTH PROFILE SCORES CHANGE OVER TIME IN CYSTIC-FIBROSIS

We have previously shown that the Nottingham Health Profile (NHP) show s good correlation xiith physiological scores in an adult cystic fibro sis (CF) population when assessing health status (HS). The aim of this study was to determine whether the NHP can detect change in HS over t ime. Patients attending an adult CF clinic Mere studied at the rime of their 'annual review' appointment. HS was assessed by the NMP and an 'in house' CF-specific score was used. FEV1% predicted, FVC% predicted , FEV1/FVC ratio, and body mass index (BMI) were calculated. The patie nts were then studied at subsequent annual review appointments. Change over time was calculated for each parameter and the relationship betw een change in IIS and change in physiological parameters was examined using Spearman's rank correlation. Initial (t1), NHP scores were obtai ned from 204 patients, median age 26 years (range 16-56 years). Follow -up scores were obtained from 152 patients (t2). The mean rate of chan ge in FEV1 was -8.6 (261) ml yr(-1) or -0.2 (6.9)% predicted yr(-1). T he only dimension of the NHP which showed a significant change over ti me was emotion, which showed a small improvement in score (score at t1 =11.3, score at t2=8.1. P=0.02). There was a significant deterioration in the CF-specific total score (t1=4.4, t2=4.7, P=0.008). There were no significant correlations between change in physiology and change in NHP scores. There was no overall difference in change in NI-IP scores between the patients whose FEV1 declined at >4% predicted yr(-1) and those u ho did not. In conclusion, although the NHP correlates well wi th one-off physiological parameters, there is pool correlation between change in NHP scores and change in physiological parameters over time .