TREATMENT OF T-PROLYMPHOCYTIC LEUKEMIA WITH ALLOGENEIC BONE-MARROW TRANSPLANTATION

T prolymphocytic leukemia (T-PLL) is an unusual disease characterized by high white cell counts, older age at presentation, splenomegaly and a very aggressive clinical course, We describe a 47-year-old male wit h refractory T-PLL who was treated with high-dose chemoradiotherapy an d allogeneic bone marrow transplantation (BMT) from an HLA-matched sib ling, The transplant was complicated by both acute and chronic graft-v ersus-host disease (GVHD), The patient achieved complete remission and remains in remission 3 years after the transplant.